.container-858 {
  max-width: 860px;
  margin: 0 auto;
  padding-inline: 0;
}
#ncc-section .ncc-left {
  background: none !important;
}
.desktopOnly {
  display: block;
}
.mobileOnly {
  display: none;
}
.red-border {
  border: 1px solid #990036;
  max-width: 800px;
}

.image-desktop-show {
  display: block;
}

.image-mobile-show {
  display: none;
}

.margin-btm-37 {
  margin-bottom: 37px;
}

.margin-top-37 {
  margin-top: 37px;
}

.margin-top-28 {
  margin-top: 28px;
}

.margin-btm-35 {
  margin-bottom: 35px;
}

.margin-top-35 {
  margin-top: 35px;
}

.margin-btm-70 {
  margin-bottom: 70px;
}

.blue-border-white-bg > .component-content {
  padding: 37px 25px 37px 25px;
  box-shadow: 0 0 5px 0 #07ecff;
  border: solid 2px #07ecff;
  border-radius: 0 15px 15px 15px;
  background-color: #fff;
}

.font-30 {
  font-family: "Antonio";
  font-size: 30px;
  font-style: normal;
  font-weight: 400;
  line-height: normal;
}

.font-13 {
  font-family: "Open Sans";
  font-size: 13px;
  font-style: normal;
  font-weight: 400;
  line-height: normal;
}

.green-text {
  color: #225063 !important;
}

.grey-text {
  color: #4c4c4c !important;
}

.red-text {
  color: #990036 !important;
}

.white-text {
  color: #fff !important;
}

#protein-overexpression-page .foot-note,
#protein-overexpression-page .references {
  max-width: 858px;
  position: initial;
}

#many-patient-demonstrate.container-1081 {
  max-width: 1081px;
  padding-top: 58px;
  padding-bottom: 58px;
  border-radius: 0 30px 30px 30px;
  background: var(
    --Section-container,
    linear-gradient(180deg, #225063 0%, #225063 53%, #071014 100%)
  );
}

#many-patient-demonstrate .container.container-858 {
  border-radius: 15px;
  background-color: #fff;
  padding: 31px 31px 53px 31px;
}

#reflexively-testing {
  font-family: "Open Sans";
  font-size: 20px;
  font-weight: bold;
  font-stretch: normal;
  font-style: normal;
  line-height: 1.3;
  letter-spacing: normal;
  text-align: left;
  padding: 18px 24px 18px 35px;
  border: solid 2px #990036;
  background-color: #fff;
  position: relative;
  border-radius: 0 10px 10px 10px;
}

#reflexively-testing::before {
  content: "";
  position: absolute;
  left: 7px;
  top: 50%;
  transform: translateY(-50%);
  background-image: linear-gradient(to bottom, #225063, #225063 14%, #990036);
  width: 11px;
  height: calc(100% - 14px);
  border-radius: 0 0 0 7px;
}

#protein-overexpression-page .hero-div {
  display: none;
}

#protein-overexpression-page #small-banner-section {
  max-width: 100%;
}
#protein-overexpression-page #small-banner-section .banner-text {
  color: #fff;
  text-shadow: 0 2px 6px rgba(0, 0, 0, 0.4);
  font-family: Antonio;
  font-size: 41px;
  font-style: normal;
  font-weight: 700;
  line-height: normal; /* 146.341% */
}

#protein-overexpression-page
  #small-banner-section
  .plain-html
  .component-content {
  margin: 0 auto;
}

#protein-overexpression-page #drives-tumorigenesis {
  font-family: "Antonio";
  font-size: 36px;
  font-style: normal;
  font-weight: 400;
  line-height: normal;
}

#shorter-survival {
  border-radius: 0px 15px 15px 15px;
  background: linear-gradient(90deg, #f2eaed 0%, #ecf0f1 100%);
  padding: 35px 0;
  margin-bottom: 35px;
}

#shorter-survival .row {
  justify-content: center;
  align-items: center;
}

#shorter-survival p.protein-text.grey-text,
.font-22 {
  font-family: "Open Sans";
  font-size: 22px;
  font-style: normal;
  font-weight: 400;
  line-height: 32px;
}

#gene-amplification .row .col-md-5 {
  display: flex;
  align-items: center;
  flex-direction: column;
  justify-content: center;
}

#gene-amplification .row .col-md-7 {
  display: flex;
  align-items: center;
  flex-direction: row;
  justify-content: center;
}

#protein-overexpression-page .image img {
  max-width: 100%;
  height: auto;
}

#protein-overexpression-page .image > .component-content {
  display: flex;
  justify-content: center;
}

#gene-amplification .row {
  display: flex;
  align-items: center;
  justify-content: center;
  gap: 60px;
}

ul.gene-amplification-list {
  font-family: "Open Sans";
  font-size: 18px;
  font-style: normal;
  line-height: 23px;
  list-style-type: disc;
  max-width: 100%;
  margin-inline: auto;
  margin-left: auto;
  margin-right: auto;
  padding-left: 25px;
}

ul.gene-amplification-list li::marker {
  color: #930046;
  font-size: 15px;
}

#biologically-distinct p.red-text.font-30 {
  letter-spacing: -0.36px;
}

#many-patient-demonstrate p.green-text.font-22 {
  font-family: "Antonio";
  margin: 5px;
}
#fgfr-protein {
  align-self: stretch;
}

#fgfr-protein p {
  width: 900px;
  margin: auto;
  position: relative;
  color: #225063;
  font-family: Antonio;
  font-size: 36px;
  font-style: normal;
  font-weight: 400;
  line-height: normal;
  letter-spacing: -0.36px;
  padding: 30px;
  padding-top: 0;
}
#fgfr-protein .highlight {
  color: var(--Burgundy, #930046);
  font-family: Antonio;
  font-size: 36px;
  font-style: normal;
  font-weight: 700;
  line-height: normal;
  letter-spacing: -0.36px;
}
#piechart-section {
  width: auto;
  max-width: 850px;
  font-family: Antonio;
  line-weight: 1.6;
  font-size: 32px;
  color: #225063 !important;
  border: solid 2px #07ecff;
  border-radius: 10px;
  position: relative;
  color: #990036 !important;
  margin: 50px auto;
  padding: 30px;
  padding-bottom: 0;
  margin-top: 0;
  box-shadow: 0 0 5px 0 #07ecff;
}

#piechart-section .p {
  display: flex;
  width: 732px;
  color: var(--Burgundy, #930046);
  font-family: Antonio;
  font-size: 30px;
  font-style: normal;
  font-weight: 400;
  line-height: normal;
}

/* Container setup */
.chart-wrapper {
  width: 100%;
  max-width: 1000px;
  margin: 40px auto;
  margin-bottom: -45px;
  font-family: Arial, sans-serif;
  position: relative;
}
#gene-amplification .red-text sup {
  margin-left: -7px;
}
.top-line {
  height: 2px;
  background-color: #c72e3a; /* red color */
  width: 100%;
  margin-bottom: 20px;
}

/* Layout */
.chart-container {
  display: flex;
  align-items: center;
  justify-content: flex-start;
  gap: 40px;
}

.pie {
  position: relative;
  width: 300px;
  height: 300px;
  top: 5px;
  left: 29px;
  border-radius: 50%;
  background: conic-gradient(
      from 0deg,
      transparent 0deg 137deg,
      #ccc 137deg 360deg
    ),
    radial-gradient(circle at center, #225063 10%, #990036 80%, #990036 100%);
  display: flex;
  align-items: center;
  justify-content: center;
  flex-shrink: 0;
}

.pie span {
  font-size: 36px;
  font-weight: bold;
  color: white;
  z-index: 2;
  transform: translate(120%, -170%);
}

.dotted-arc {
  position: absolute;
  top: 0;
  left: 0;
  width: 320px;
  height: 320px;
  pointer-events: none;
  z-index: 2;
}
.chart-container .info {
  max-width: 400px;
  border-radius: 10px;
  color: #333;
  line-height: 1.5;
  font-size: 16px;
}

.info .highlight {
  color: #960f3c;
  font-weight: bold;
}

.info .line1 {
  font-weight: bold;
  font-size: 16px;
  width: 300px;
  margin: 20px;
}

.info .line2 {
  font-size: 16px;
  width: 300px;
  border: 1px solid skyblue;
  border-radius: 5px;
  padding: 30px;
  line-height: 1.6;
  font-weight: bold;
  height: 200px;
  margin-right: 50px;
}

info .line2.highlight {
  color: var(--Burgundy, #930046);
  font-family: Antonio;
  font-size: 30px;
  font-style: normal;
  font-weight: 700;
  line-height: normal;
}
svg {
  position: absolute;
  top: 0;
  left: 0;
  width: 320px;
  height: 320px;
  pointer-events: none;
  z-index: 2;
}
.radial-line {
  stroke: #00e4ff;
  stroke-width: 2;
  stroke-dasharray: 3 3;
  stroke-linecap: round;
}

.arc-dotted {
  fill: none;
  stroke: #00e4ff;
  stroke-width: 3;
  stroke-dasharray: 6 4;
}

.arc-solid {
  fill: none;
  stroke: #00e4ff;
  stroke-width: 2;
}
.chart-legend {
  display: flex;
  flex-direction: column; /* stack vertically */
  gap: 10px;
  margin-top: 20px;
  font-family: Arial, sans-serif;
  font-size: 14px;
  color: black;
}

.legend-item {
  display: flex;
  align-items: center;
  gap: 8px;
}

.legend-color {
  width: 14px;
  height: 14px;
  border-radius: 3px;
  display: inline-block;
}
.pie-color {
  background-color: linear-gradient(to right, #225063 -5%, #990036);
  background-color: #990036;
}

.failure-color {
  background-color: #e0e0e0;
}

.navigation-arrows {
  color: black;
}
.navigation-arrows .first-line {
  width: 50px;
  color: black;
  position: absolute;
}
.navigation-arrows .vertical-line {
  width: 50px;
  color: black;
  position: absolute;
}
.navigation-arrows .second-line {
  width: 50px;
  color: black;
  position: absolute;
}
.navigate-container {
  background: url(/-/media/A8C8F55435A04AA8A810C7BE418C30B5) no-repeat center;
  position: relative;
  width: 220px;
  height: 150px;
}

.navigate-dot {
  background: url(/-/media/B910B058-EAA54D6AA5FC7D6DF1382683) no-repeat center;
  position: absolute;
  right: -7px;
  top: 33px;
  width: 8px;
  height: 8px;
  background-color: #930046;
  border-radius: 50%;
}

#shorter-prognostic {
  margin-bottom: 73px;
}
.blue-text {
  color: #225063;
  -webkit-text-stroke: 0.45px #07ecff;
  font-weight: 800;
}
#shorter-prognostic .col-xl-12:nth-child(1) {
  order: 2;
}
#shorter-prognostic .col-xl-12:nth-child(2) {
  order: 1;
}
#shorter-prognostic .col-xl-12 {
  padding: 0;
}
.marg-1,
.marg-2 {
  margin-bottom: 19px;
}
.marg-3 {
  margin-bottom: 25px;
}
#protein-overexpression-page #reference-section {
  display: none;
}

#gene-amplification {
  margin-bottom: 73px;
}
#biologically-distinct > .component-content {
  padding-bottom: 0;
}
.text-point {
  font-size: 16px;
  font-weight: normal;
  line-height: 1.38;
  letter-spacing: normal;
  text-align: left;
  color: #4c4c4c;
  padding: 0 0 0 14px;
  margin: 0 0 48px;
  position: relative;
}
.text-point::before {
  position: absolute;
  content: "";
  background-color: #930046;
  width: 5px;
  height: 5px;
  border-radius: 50%;
  top: 9px;
  left: 3px;
}
.mar-top {
  margin-top: 39px !important;
  margin-bottom: 0 !important;
}

@media screen and (max-width: 991px) {
  .container-858,
  #many-patient-demonstrate.container-1081 {
    padding-inline: 15px;
  }
  ul.gene-amplification-list {
    max-width: 95%;
  }
}

@media screen and (max-width: 767px) {
  .desktopOnly {
    display: none;
  }
  .mobileOnly {
    display: block;
  }
  .image-desktop-show {
    display: none;
  }

  .image-mobile-show {
    display: block;
  }
  #protein-overexpression-page #drives-tumorigenesis {
    padding-top: 20px;
    margin-top: 0;
    position: relative;
    margin-bottom: 48px;
  }
  #protein-overexpression-page #drives-tumorigenesis p {
    font-size: 32px;
  }
  #shorter-prognostic {
    margin-bottom: 48px;
  }
  .blue-border-white-bg > .component-content {
    padding: 32px 16px;
  }
  .margin-top-28 {
    margin-top: 24px;
  }
  .margin-btm-37 {
    margin-bottom: 40px;
  }
  ul.gene-amplification-list {
    line-height: 1.33;
    padding-left: 18px;
  }
  .blue-border-white-bg.margin-btm-35 {
    margin-bottom: 48px;
  }
  .blue-border-white-bg.margin-btm-70 {
    margin-bottom: 48px;
  }
  #many-patient-demonstrate.container-1081 {
    max-width: calc(100% - 32px);
    margin-left: auto;
    margin-right: auto;
    padding-top: 24px;
    padding-bottom: 24px;
  }
  .container-858 .margin-btm-35 {
    margin-bottom: 32px;
  }
  #many-patient-demonstrate .container.container-858 {
    padding: 32px 16px;
  }
  #many-patient-demonstrate p.green-text.font-22 {
    line-height: 1.18;
  }
  .container-858 .landscape-line {
    margin: 23px 0 32px;
  }
  .container-858 p.margin-top-35 {
    margin-top: 32px;
  }
  #many-patient-demonstrate.container-1081.margin-btm-70 {
    margin-bottom: 48px;
  }
  .container-858,
  #many-patient-demonstrate.container-1081 {
    padding-inline: 16px;
  }
  .marg-1,
  .marg-2 {
    margin-bottom: 20px;
  }
  .marg-3 {
    margin-bottom: 24px;
  }
  #biologically-distinct > .component-content {
    padding-bottom: 0;
  }
  #protein-overexpression-page #biologically-distinct .image-mobile-show {
    padding: 20px 0;
  }
  #gene-amplification {
    margin-bottom: 48px;
  }
  .text-point {
    margin-bottom: 32px;
  }
  .gastric-cancer-and-biomarkers #footnote-small-text {
    margin-top: 48px;
  }
  .mar-top {
    margin-top: 21px !important;
    margin-bottom: 0 !important;
  }
  #protein-overexpression-page #small-banner-section .banner-text {
    font-size: 30px;
  }

  #fgfr-protein {
    max-width: auto;
    align-self: stretch;
    margin-bottom: 48px;
  }

  #fgfr-protein component-content {
    max-width: auto;
  }

  #fgfr-protein p {
    max-width: 100%;
    color: #225063;
    font-family: Antonio;
    font-size: 31px;
    font-style: normal;
    padding: 0;
    margin: auto;
  }
  #fgfr-protein .highlight {
    max-width: 100%;
    color: var(--Burgundy, #930046);
    font-family: Antonio;
    font-size: 31px;
  }

  #piechart-section {
    max-width: 100%;
    color: var(--Burgundy, #930046);
    font-family: Antonio;
    font-size: 30px;
    font-style: normal;
    font-weight: 400;
    line-height: normal;
    margin: 16px;
    padding: 16px;
    padding-bottom: 0;
    box-shadow: 0 0 5px 0 #07ecff;
  }
  .chart-wrapper {
    margin: 20px auto;
  }
  #protein-overexpression-page .image > .component-content {
    display: block;
  }
}

.marker {
  margin-right: 0 !important;
}

.hanging-indent {
  text-indent: -15.5px !important;
}
#cancer-and-biomarkers-statement p {
  margin-bottom: 4px !important;
}

.fgfr2b-stain-interpretation #small-banner-section {
  padding-bottom: 165px;
}